淘汰、洗牌——这是多数业内人士对两年前“ 7· 22 数据核查风暴”以及一致性评价政策这套“组合拳”政策将带来的影响所做的行业预言。如今两年过去，国家食品药品监督管理总局于近日公布了这场最严核查风暴的初期疗效，从公布的数据来看，在中国有相当比例的临床数据涉嫌数据造假。如今，涉及 1300 多个品种撤回的企业面临药物研发成本短期难以收回的现实，而被查出数据造假的企业三年内不得再次申请临床。在 A 股市场，超过一半数量的医药上市公司因此被波及，更惨的是资本、研发实力欠佳的数千家中小型仿制药企业，数据核查及一致性评价风暴的双管旗下，让过去同质化、缺乏市场份额的中小仿制药企难以度日，在中国近 5000 家的医药企业中，这一类型的企业占据了三分之一。

8 月 2 日，CFDA 官网公布了《药物非临床研究质量管理规范》（简称《规范》），自 2017 年 9 月 1 日起施行。早在 2003 年，国家食品药品监督管理局发布施行《药物非临床研究质量管理规范》（原局令第 2 号），随着我国药物非临床安全性评价研究能力的不断提升和评价数量的快速增长，以及药物非临床研究领域新概念的产生和新技术的应用，需要对于药物非临床研究质量管理规范内容调整和细化，以适应行业发展和监管工作的需要。

猪瘟疫苗竞争激烈，市场较为成熟。1）行业规模：据草根调研，2016年猪瘟市场规模约 10 亿元；2）渗透率：约95%，其中市场苗以中大规模养殖户为主要客户；3）竞争格局：企业数量超过 50 家且均有国内企业，主要竞争企业疫苗产品线基本覆盖脾淋苗、细胞苗及传代细胞苗；4）细胞苗为主：目前市场上细胞苗使用占比约为 90%；5）市场空间：据我们初步预估，在规模化及市场化推动下，猪瘟市场苗空间约 15 亿元。

Patient monitoring systems are used for the measurement of a patient's medical parameters such as heart rate, blood glucose level, blood-oxygen saturation, blood pressure, and other parameters. There are various types of patient monitoring systems, which help in the regular or continuous monitoring of a patient's medical wellbeing. The majority of the patient monitoring systems are connected to life-support devices. The existing patient monitoring systems measure parameters such as invasive and non-invasive blood pressure, dual temperature, oxygen saturation (SPO2), partial carbon dioxide level, and other related parameters. Some of the factors impacting the growth of the patient monitoring systems during the forecast period are use of blood gas analyzers, drug dosage monitoring, real-time patient location system, wearable patient monitoring devices, and telemedicine.

Biopsy is a clinical procedure primarily used in the detection and extraction of malignant or cancerous cells and their abnormal growth in the body for further analysis and interpretation of diseases. The purpose of removing tissues or cells during the procedure is mainly to limit the spread of tumor, minimize morbidity, and eliminate interference with future treatments.

Ba29sed on the target market and product pricing, the beauty products industry can be divided into two broad categories: mass beauty care and premium beauty care. While the mass category is targeted at the middle- and lower-income class (C, C-/D+, and D/E class) population, the premium category is targeted at the upper-income class (A/B and C+) or affluent class of the population.

mHealth segment is expected to witness the fastest growth in the market, due to the increase in healthcare cost, the demand for patient centric healthcare model,and the occurrence of chronic and lifestyle-related diseases.The Americas had the largest share of the smart healthcare market in 2015, due to the presence of sophisticated IT infrastructure that enables the easy implementation of advanced healthcare facilities.Most wearable healthcare devices function on GPS, wireless networks, and M2M technology. Therefore, the battery life of these devices is very low because of their high power consumption. This also affects the durability of these devices and,therefore, has the potential to affect the demand for smart wearable healthcare devices in the coming years, which will have a direct impact on the market.This report covers the present scenario and the growth prospects of the global smart healthcare market from 2016-2020.

Talc is a soft mineral, which is chemically composed of magnesium, silica, and water.The chemical composition for talc is hydrated magnesium silicate. The chemical formula usually remains close to this generalized composition but sometimes there are variations in the structure due to the substitution of magnesium by other elements.When ferrous ions substitute magnesium ions of talc, then minnesotaite is formed.Similarly, when aluminum ion substitutes magnesium, then pyrophyllite is formed. Talc has the tendency to form pseudomorphs from different minerals. Some of the commonly pseudomorphed minerals are quartz, dolomite, pyroxenes, and calcite.Kerolite, magnesium talc, soapstone, and steatite are the terms that are generally used for referring talc.

Radiography is a technique that uses gamma rays and X-rays to produce images of objects. These images can be used to identify certain deformities or defects that are not visible to the bare eye. The object to be tested is subjected to radiations using a generator, while a film or digital detector is used to take the image of the object. The darker areas on the image indicate high levels of radiation, whereas lighter areas indicate low levels. This is the basic principle for the functioning of radiography equipment. However, newer technologies such as CT, CR, and digital radiography can produce high-quality images in 3D, allowing for better analysis.

Stem cell therapy is the use of stem cells for the treatment or prevention of a disease or condition. Bone marrow transplant is the widely used stem cell therapy, followed by therapies derived from umbilical cord blood. Research is being undertaken to develop various sources (such as cord blood cells, bone marrow, and skin) for stem cells, and to apply them to various disorders like neurodegenerative diseases and conditions such as heart disease, diabetes, and other conditions.Stem cell therapy has become controversial after development in isolating and culturing of embryonic stem cells. This technique is used to create stem cells using somatic cell nuclear transfer and to create induced pluripotent stem cells (iPSCs). This controversy is related to abortion politics and human cloning. However, the changing regulatory landscape in several countries such as the US and Japan may help accelerate the clinical trials.

Endoscopy is a minimally invasive procedure used for diagnosis, prevention, and treatment of complications in the internal organs of the body. An endoscope is introduced into the individual's body either through natural cavities or through a small incision. The bronchoscope is an instrument used to visualize the inside airway through mouth or nose to observe the distal branches of the bronchi. This technique helps to observe the pulmonary malignancies from the sample taken through working channels of the bronchoscope. Also, a physician can install radiographic media for bronchographic studies, remove foreign objects, perform laser therapy, perform difficult intubations, and insert catheters.

本周市场呈现出分化的态势，周期性板块如钢铁、有色金属等出现了回调，而医药等非周期性板块则表现较活跃。目前医药行业的估值溢价率已经降至近年来的低点，同时行业利润增速良好，我们认为未来跑输沪深 300 指数的概率不大，有望取得超额收益。

国务院发布《关于印发水污染防治行动计划的通知》，要求 2017 年底前，制药（抗生素、维生素）行业实施绿色酶法生产技术改造,目前已经进入最后阶段。除此之外，2017 年4 月开始，环保部对京津冀及周边地区 28 个城市开展的大气污染防治强化督查，号称是“史上最大规模环保督查”。

研究分析河南省医用氧生产企业实施新版药品GMP存在的主要问题，为有效实施新版药品GMP提供建议。方法：对本省34家医用氧生产企业的45次GMP认证跟踪现场检查发现的缺陷进行统计和分析。结果与结论：本省医用氧生产企业在质量管理与质量控制、文件管理、设备管理、机构与人员、确认与验证、生产管理等方面还存在不足，企业应当持续不断的改进质量管理体系，从而确保产品质量。

公立医院改革是医改的关键任务，根据进展来看，药品零差率销售与调整医疗服务价格的改革措施存在显著的效果边界，不能从根本上切断和改变医生诱导需求的内在动机。调整公立医院薪酬制度进而调动医务人员的改革积极性被认为是下一步改革的关键，也是公立医院改革最深层的机制问题。本研究从三明市公立医院改革整体政策框架入手，理清包括薪酬制度改革在内的各项改革政策措施的内在逻辑，分析其作用边界，并明确依靠薪酬制度改革解决深层次机制问题的逻辑基础，说明割裂的依靠某个或几个政策无法取得整体性的改革效果，对公共政策体系性和整体性的深入认识，有助于对当前公立医院改革的核心节点和进展步调进一步达成共识。

分析互联网药品销售监管体系存在的主要缺陷并提出对策，为加强互联网药品销售安全监管提供参考。方法：阐述国内网上药品销售发展现状和违法表现，分析互联网药品销售监管体系存在的主要缺陷。结果与结论：从修订法规文件、健全监管体制、完善技术手段、加大监管力度、促进社会共治等几个方面，提出完善互联网药品销售监管体系的对策。

本文结合病种付费制度改革和ERCP技术推广的现状，分析了ERCP价格政策及对患者费用影响，并提出政策建议。ERCP耗材属于“低价”高值医用耗材，但9类疾病患者住院费用中耗材费占比达到35.81%～48.25%，是导致费用昂贵的主要因素之一。由于ERCP耗材未纳入医保支付范围，目前这类患者手术自付比率高、医疗费用昂贵。建议：（1）重视历史结算数据，科学制定病种收费标准；（2）参考治疗方式差异，分类制定病种支付标准；（3）规范手术操作编码，为病种费用测算提供精准数据支持。

目的：了解我国医生对正向执业环境的评价，从卫生服务供方角度提出对医改的建议。方法：采用自行设计的医务人员正向执业环境调查表，对全国7个省/直辖市的77家公立医院的3 564医生进行问卷调查。正向执业环境包括组织管理和医患关系两个维度。结果：医生的正向执业环境评分仅18.02±4.86分（满分40分），组织管理维度的评分高于医患关系；组织管理维度中，评分最低的是组织对个人建议的重视（2.24±1.04）；医患关系维度中，评分最低的是规避医疗风险（1.59±0.81）；不同地区医生的正向执业环境评分存在差异，西部地区医生的评分最低（P＜0.001）；中医的正向执业环境评分高于西医（P＝0.002）。结论：目前医生的执业环境不容乐观，医院外部紧张的医患关系比医院内部低效的组织管理更严重；促进正向执业环境，医院应采用参与式决策管理模式、建立向医院基层倾斜的宽带绩效薪酬制度；政府应以促进医患信任为基本价值取向，建立合理的医院补偿激励机制。

目的：分析2011年和2014年我国西部少数民族边远地区农村居民现金卫生支出（out-of-pocket，ap）对贫困的影响。方法：利用2011年和2014年家庭入户调查数据，比较国家贫困标准下当地居民OOP发生前后的贫困发生率和贫困差距等指标。结果：2011年，OOP前后贫困发生率为31.07%和51.70%，致贫影响为20.63%，平均贫困差距增加284.24元，相对贫困差距增加183.73元；2014年，OOP前后贫困发生率为29.40%和44.66%，致贫影响为15.26%，平均贫困差距增加242.68元，相对贫困差距增加240.41元。结论：当地居民贫困发生率和平均贫困差距有所下降，但相对贫困差距上升；需要进一步调整新型农村合作医疗补偿方案，提高居民受益水平；重点关注低收入人群，减少因病致贫、因病返贫的现象。

随着新医改的推行，我国在药品流通体系方面进行了一系列改革探索，但药品层层加价仍是药价居高不下的主要原因。为减少流通环节，国务院医改办提出在全国范围内推广并试行“两票制”。药品配送模式作为影响药品流通价格体系的重要环节，对“两票制”政策的具体落实将产生重要影响。本文将结合“两票制”政策，探讨我国典型配送模式。以福建省和陕西省为代表，对各模式的实施主体、实施形式进行概括，多方面分析各模式利弊所在，提出最优的配送方案，为我国下一阶段完善“两票制”提供政策建议。