Biomanufacturing is the process of production of commercially important biomolecules by utilizing biological systems for use in medicines, food and beverage processing, and industrial applications. Natural sources such as blood, cultures of microbes, animal cells, or plant cells are often employed to carry out biomanufacturing. Cells used in the production process can also be derived using genetic engineering techniques. Biomanufacturing refers to the method of production of biological products from living cells that are commercially important for use in medicines, food and beverage processing, and industrial applications. It is a form of biotechnology that encompasses the use of biomaterials harvested from natural sources such as microbes, blood, animal cells, or plant cells. These cells or ingredients used in the production are either naturally occurring or are synthesized through genetic engineering. In the field of medicine, several biopharmaceutical products such as vaccines, cytokines, amino acids, growth factors, antibodies, and fusion proteins are all manufactured through bioprocessing and are hence called biomanufactured products. The terms “bioprocessing” and “biomanufacturing” are often used interchangeably, the former representing the technologies and system processes, whereas the latter involves implementing bioprocessing practices to produce commercially important biomaterials and biomolecules for specific applications. One key feature distinguishing a biomanufactured product such as monoclonal antibodies from small molecule drugs such as aspirin is their production process. Biomanufacturing is a highly complex, multi-step procedure requiring much more time and expense than that needed for small molecules.

Molecular diagnostics encompasses a rapidly evolving range of assays and systems that facilitate pathogen detection, viral load estimation, antibiotic and antiviral therapy selection, diagnosis of cancer, and other diseases, by the detection and analysis of proteins and nucleic acid sequences. Molecular diagnostics also offer prognostic assessments for a wide range of diseases, as well as assistance with treatment selection and monitoring of drug treatment efficacy. Molecular diagnostics has evolved to be an integrative aspect of healthcare routines by providing most laboratory tests in infectious disease and genetics, and a continuously increasing number of tests in oncology. The massively parallel methods that have now transcended molecular diagnostics allow sequencing of entire genomes at very low costs. The sequenced databases within and between species provide the information necessary for the development of sensitive and specific diagnostic assays. The effect of extensive sequencing procedures has led to most microorganisms today being classified on the basis of sequence rather than phenotype. A presumptive diagnosis is made if a microbial sequence is present where it should not be.

CRISPR is a technology that is used in gene editing enabling researchers and scientists globally to alter DNA sequence and modify gene function with ease. CRISPR gene editing was adopted from the antivirus immunity system of single-celled microorganisms, namely archaea and bacteria. Fragments of alien DNA, known as a spacer, are incorporated and transcribed into guide crRNA (CRISPR RNAs) to specifically target and cleave the genome of the virus and other foreign bodies using Cas proteins. In other words, the CRISPR/Cas9 system directs the Cas9 nuclease to form a site-directed double-strand DNA break using a small RNA molecule that results in permanent alterations of the genomic target sequence and repair the damage caused to DNA. These components, when transferred into more complex organisms, enable gene editing or modifications.

Indoor farming is an important part of modern agriculture for producing crops in a controlled environment. There is an increasing growth for indoor farming globally propelled by the rising world population along with a consequent demand for consistent food supplies. Conventional agriculture is suitable for areas with sufficient land and water supply. Since the percentage of arable land and water supply to support conventional agriculture is diminishing, the demand for indoor farming is heightening. Indoor farms can help to grow the total crop yield per unit area by utilizing the stacked layers of potted seeds, and this is further expected to drive the market. Indoor farming mainly implements methods, including aquaponics, aeroponics, and hydroponics also utilizes artificial lighting such as LED lights for adequate light levels and nutrients. Indoor farming method or concept further employs various technologies that become the means of operation. For instance, to collect data, indoor farming depends on the Internet of Things (IoT), GPS, and other sensor-based technologies, which allow seamless data collection. For data analysis, several farm management software and artificial intelligence (AI) based tools can be utilized to make sense of the collected data, and later autonomous machines and other mechanical equipment can be employed to take necessary actions.

Digitalization is defined as the ability to harness collective technological advances in computing power, data collection, processing, storage, and networking between computer devices. The term must be differentiated from digitization, which simply means the conversion of analog to digital, e.g., converting a printed photograph into a JPEG* file. Defense forces have always pursued digitalization; however, its adoption has lagged behind commercial industries in recent times. Historically, computers have been used to manage logistics, supply inventory, pay wages, and maintain personnel records. There is also a rapid increase in digital adoption on the battlefield with advances in automated processing and sensor technologies.

Preimplantation genetic diagnosis (PGD) is performed among couples with a higher risk of transmitting a genetic condition to their offspring. The technique is employed in in-vitro fertilization centers globally to select the euploid embryos to transfer and improve the clinical outcome of the clinical pregnancy, embryo implantation, and live birth rates. As per a research study published by MDPI, embryo aneuploidy is one of the significant reasons for IVF failure enhancing the importance of the preimplantation genetic testing for aneuploidies as a mode of selecting healthy embryos with normal chromosomes. The ability to identify the preimplantation embryos with the genetic defects prior to the initiation of the pregnancy also offers an attractive alternative to chorionic villous sampling or amniocentesis.

The study defines cancer microbiome as the aggregate of microorganisms living in or on the human body along with their genomes that are influencing cancer manifestation and progression. Cancer microbiome sequencing has increasingly become an area of interest for the research community, which has the potential to revolutionize cancer care, largely due to studies that have significantly correlated the microbiome’s involvement in cancer manifestation. This study aims at deciphering the potential of the cancer microbiome sequencing and its larger role in bolstering the current era of precision medicine.

The recent technological advancement in the field of next-generation sequencing (NGS) and cell and molecular biology has given birth to the new era of precision medicine, which offers a platform to analyze the variability in genes, lifestyle, and environment of each person individually. Now, the researchers have found an even better option through cell sequencing, which precedes the advancements of next-generation sequencing. In the past few decades, whole genome sequencing (WGS) and whole transcriptome sequencing (WTS) methods have been applied to single cells to combine DNA, RNA, protein, and chromatin information through a single cell. The transcriptomics technique has enabled researchers to use genomics, proteomics, transcriptomics, and epigenomics to understand the heterogeneity of genetically identical cells in the same tissue.

Epigenetics modification, including histone modification, DNA methylation, and RNA-mediated processes modification, are key to impact gene expression primarily at the level of transcription; disturbing any of three marks that contribute to epigenetic modification can cause abnormal activation or silencing of genes. However, other steps in the process (for example, translation) may also be regulated epigenetically. The current study aims to assess the global epigenetics market by focusing on products (consumables, instruments, software) catering to end users, including pharmaceutical and biotechnology companies, academic and research institutions, contract research organizations (CROs), and other end users. The current market for epigenetics is majorly dominated by manufacturers and service providers such as Thermo Fisher Scientific Inc, Illumina, Inc, Bio-Rad Laboratories, Inc, PerkinElmer Inc, Agilent Technologies, Inc, F. Hoffmann-La Roche Ltd., Exact Sciences Corporation, Merck Group, Abcam plc., MDxHealth, Pacific Biosciences of California, Inc, QIAGEN N.V., Zymo Research Corporation, Active Motif, and Promega Corporation among others.