化学原料药是我国的主要医药产业，也是我国出口的主要药品之一。本文从竞争力的角度研究了各省市化学原料药行业的状况，发现我国化学原料药行业的竞争力有所上升，但总体的竞争力水平不高；四大地区中，东部地区化学原料药的竞争优势最明显，东北部的竞争优势最弱。

《中国联合商报》报道，为配合6月1日起实施的《医疗器械监督管理条例》，国家食品药品监管总局8月1日公布了新制修订的《医疗器械注册管理办法》、《体外诊断试剂注册管理办法》、《医疗器械说明书和标签管理规定》、《医疗器械生产监督管理办法》和《医疗器械经营监督管理办法》等五部规章，将于10月1日起施行。

报告从医药行业事件分析、竞争环境、竞争对手、行业数据等几个方面进行了分析评论。

论文以生物技术药物产业为研究对象，分析总结了生物技术药物的特性、现阶段主要上市产品、研究重点领域和发展前景。论文还研究了我国生物技术药物产业的现状，并借鉴国外经验，提出了发展我国生物技术药物产业的对策建议。

报告从产业动态、产业分析、技术趋势、企业跟踪、地方动向等几个方面对生物科技产业进行了分析评论。

Multiple sclerosis is a chronic, inflammatory medical condition, which results in demyelination, axonal transection, and neurodegeneration of the nerve cells of the brain and spinal cord. The immune system of the body targets the neurons within the CNS and damages the myelin sheath. It is a potentially debilitating disease, causing disruption in the communication and coordination functions of the body. The symptoms of multiple sclerosis differ widely, subject to the extent of damage and the number of neurons affected. Some of the symptoms observed are fatigue, numbness, spasticity, bladder dysfunction, cognitive changes, emotional changes, and depression. An individual with severe form of the disease can experience speech and movement problems. Multiple sclerosis can be broadly classified into four types: RRMS, SPMS,PPMS, and PRMS.

Meningitis is characterized by inflammation of the protective lining (meninges) present around the brain and spinal cord. On the basis of its underlying cause, meningitis can be classified into infectious and non-infectious meningitis.

Hodgkin's lymphoma is a cancer of the lymph tissue. The exact etiology of Hodgkin's lymphoma is unknown. However, the risk of developing the condition increases if a person suffers from a medical condition that weakens the immune system. In Hodgkin's lymphoma, cells in the lymphatic system grow unusually and may spread beyond the lymphatic system. The infectionfighting properties of the lymphocytes are lost, making the person more susceptible to the infection. Chemotherapy is the main treatment used for treating the condition, followed by radiotherapy.

Intranasal drug delivery is used to treat local diseases in the nose and paranasal sinus such as allergic and non-allergic rhinitis and sinusitis. The nose is considered an ideal administrative route for needle-free vaccination and systematic drug delivery. Continuous advances in technology in intranasal drug delivery products help achieve efficient treatment. Intranasal drug delivery systems provide an easy mode of administration for patients on long-term therapy, avoid risk of overdose, and enhance the bioavailability of the drug.

A peptic ulcer is an open lesion that develops on the mucosal lining of the stomach and small intestine because of the caustic effect of the gastric acids and enzymes in these organs. The symptoms of peptic ulcers are pain in the abdomen, nausea, vomiting, and bloated stomach. The major symptoms include bleeding from the ulcer, which can be life-threatening. It is detected by bloody and sticky stools, often black in color. Peptic ulcers are caused mainly by a Helicobacter pylori infection followed by the overuse of OTC NSAIDs such as Naproxen, Aspirin and Ibuprofen. Peptic ulcers can be of two types based on the site of the ulcer: gastric ulcer and duodenal ulcer.

The Division of Cancer Treatment and Diagnosis (DCTD) takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other diagnostic and therapeutic interventions (radiation, surgery, immunotherapy) in patients.

Triple-negative breast cancer (TNBC) is a heterogeneous mix of cancers defined only by the absence of the three best-characterized prognostic markers: estrogen receptor (ER), progesterone receptor (PR), and the human epidermal growth factor receptor 2 (HER2). This lack of understanding underlies our inability to identify effective therapeutic options for these patients. During the previous research period for this award (year 1), we identified that a subset of TNBCs have high baseline levels of activated EGFR, and were sensitive to certain temporal combinations of EGFR inhibition and DNA damaging chemotherapy. The focus of this research period (year 2) was to determine the mechanism of this enhanced sensitivity to chemotherapy. Using an integrative analysis of multiple signaling networks, we identified that chronic exposure to EGFR inhibition in a subset of TNBCs resulted in a profound genetic rewiring, resulting in more than 2000 differentially expressed genes (DEGs). Further analyses revealed that caspase-8 played a crucial role in the combination therapy we identified, a surprising and unexpected finding, since this protein was not previously thought to contribute to DNA damage-induced cell death. Collectively, these findings identify a novel method for enhancing chemotherapeutic efficacy, through rewiring apoptotic signaling networks.

本刊以七大战略性新兴产业——高端装备制造、节能环保、新能源、新材料、新能源汽车、生物、新一代信息技术为研究重点，关注国家高层和各部委的动态，剖析国家和地方的新兴产业政策。本刊设有政策导读、领导讲话、七大战略性新兴产业本周国内外行业动态和重点企业新闻、投资专题四大板块，能够实时监测新兴产业和重点企业动态，把握新兴产业发展方向，研究发展重点，寻求发展机遇。

本刊以七大战略性新兴产业——高端装备制造、节能环保、新能源、新材料、新能源汽车、生物、新一代信息技术为研究重点，关注国家高层和各部委的动态，剖析国家和地方的新兴产业政策。本刊设有政策导读、领导讲话、七大战略性新兴产业本周国内外行业动态和重点企业新闻、投资专题四大板块，能够实时监测新兴产业和重点企业动态，把握新兴产业发展方向，研究发展重点，寻求发展机遇。