报告从政策环境、市场行情、厂商动态、科技研发、国际资讯、行业数据、分析评论等几个方面对医药行业进行了分析评论。

报告从医药行业事件分析、竞争环境、竞争对手、行业数据等几个方面进行了分析评论。

2014 年1-2 月，医药制造业企业单位数为6778 家。全行业实现销售收入3104.9 亿元，同比增长13.5%，同比增速比2013 年同期减少9.2 个百分点；利润总额为298.8 亿元，同比增长15.0%，同比增速比2013年同期减少9.3 个百分点；销售利润率为9.6%，比2013 年同期增加0.2个百分点。

Surgical navigation is a procedure used to locate a specific target site for surgery using computer software.

PCR is a molecular genetics technique used to amplify and analyze nucleic acids. It is a very precise, specific, and accurate technique that can amplify a specific DNA target from a mixture of DNA molecules. It is used in a wide array of applications in research and diagnosis including genetic engineering, cloning, sequencing, diagnosis, genotyping, and many other areas. The advances in PCR technology and tools provide high reproducibility in a short period. Depending on the requirement, PCR reaction involves different types of reagents, consumables, and instruments to process the sample. The advanced software helps to analyze data generated from the sample under process.

目的探讨PCI围手术期血清N末端脑钠肽前体（N-terminal pro-B-type natriuretic peptide,NT-PROBNP）和肌钙蛋白（cardigc troponin,cTn）联合检测在老年急性冠脉综合征（acute coronary syndrome,ACS）中的应用。方法选取2013年4月2014年4月期间山东省聊城市第二人民医院收治的67例需行PCI治疗的老年ACS患者为研究对象,选取同期健康老人30例作为对照。检测并比较2组研究对象围手术期血清NT-PROBNP和cTn水平,分析血清NT-PROBNP和cTn与老年ACS患者心功能的关系,并采用ROC曲线分析血清NT-PROBNP和cTn联合检测对老年ACS患者心功能的预测能力。结果老年ACS患者血清cTnT、cTnI和NTPROBNP水平均较健康老人显著升高（P<0.05）,术后4h、12h和24h老年ACS患者的血清cTnT、cTnI和NT-PROBNP水平均较术前升高,术后72h患者血清cTnT、cTnI和NT-PROBNP水平逐渐降至术前水平或更低,术后4h、12h和24h各时间点之间的血清cTnT、cTnI和NT-PROBNP水平比较差异均有统计学意义（P<0.05）。Pearson相关性分析结果显示:血清cTnT、cTnI和NT-PROBNP水平与老年ACS患者心功能均呈负相关(rcTnC=-0.675,rcTnT=-0.706,rcTnI=-0.841,rNT-PROBNP=0.822,P<0.05)。ROC曲线下面积可信区间0.6780.945,0.6≤A≤0.9,提示血清NT-PROBNP和cTn联合检测对老年ACS患者心功能的预测价值良好。结论老年ACS患者血清NT-PROBNP和cTn水平与老年ACS患者患者心功能均呈负相关,血清NT-PROBNP和cTn联合检测可作为行PCI的老年ACS患者心功能的预测指标。

目的：探讨非诺贝特(fenofibrate，FENO)预处理对小鼠肾缺血再灌注损伤的保护作用及其机制。方法：建立小鼠肾缺血再灌注损伤模型。24只C57BL/6小鼠，♂，随机分为3个组(n=8)，分别为假手术组(Sham组)、肾缺血再灌注损伤模型组(IRI组)和非诺贝特预处理组(FENO组)。Sham组、IRI组和FENO组经不同方法处理后，经PAS染色观察肾脏病理学形态学变化，Western blot检测JAK2和 STAT3，p-JAK2，p-STAT3，Caspase 3表达情况。结果：与Sham组相比，IRI组血清肌酐和血尿素氮水平明显升高，病理检查可见肾脏内肾小管上皮细胞肿胀坏死变多、蛋白管型形成明显，还可观察到炎症细胞浸润增加显著；Western blot显示p-JAK2和p-STAT3，蛋白表达量均明显增加，JAK2和STAT3表达无明显变化，但Caspase 3 表达显著减少。与IRI组相比，FENO组血清肌酐和血尿素氮量明显下降，肾小管上皮细胞肿胀坏死减轻，炎症细胞浸润变少、蛋白管型形成减少，p-JAK2和p-STAT3表达明显降低，Caspase 3表达增加，JAK2和STAT3表达无明显变化。结论：FENO预处理小鼠可通过抑制JAK2/STAT3信号通路的激活从而减少肾小管上皮细胞凋亡，进而减轻肾缺血再灌注损伤。

Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome2 was sequenced in 1995 and took more than 13 months of work to complete. Today (2012), a microorganisms entire genome can be sequenced in a few days. Much as our view of the cosmos was forever altered in the 17th century with the invention of the telescope (Nee, 2004), these genomic technologies, and the observations derived from them, have fundamentally transformed our appreciation of the microbial world around us.