此轮牛市中，中药板块整体跑输，且相对A 股的估值溢价率一直处于下降通道中。

2015年1-5月医药工业收入增8.86%，创10年新低，利润增11.49% 。和“十一五”期间行业增速均值超过20%相比，由于行业增长基线大幅下移，我们以业绩增速角度来评判企业发展阶段癿标尺也需变化。

报告从产业动态、产业分析、技术趋势、企业跟踪、地方动向等几个方面对生物科技产业进行了分析评论。

报告从医药行业事件分析、竞争环境、竞争对手、行业数据等几个方面进行了分析评论。

报告从政策环境、市场行情、厂商动态、科技研发、国际资讯、行业数据、分析评论等几个方面对医药行业进行了分析评论。

截止到 2015 年7 月17 日我们采用一年滚动市盈率（TTM，整体法），剔除负值影响，医药生物整体市盈率处在54.6 倍，比上周有所升高，仍高于历史估值均值。

Retinoblastoma is rare eye cancer that occurs predominantly in children younger than 15 years old. It accounts for nearly 3% of pediatric cancer cases worldwide. It is a genetic disorder that originates in the retina and slowly progresses toward the outer part of the eye. The growth of the tumor can be endophytic, exophytic, or diffuse infiltrating. In the endophytic pattern, the tumor grows into the vitreous cavity; however, the retinal blood vessels are not visible on the surface of the tumor. In the exophytic pattern, the tumor grows close to the subretinal space; the presence of retinal blood vessels in the tumor surface is also observed. The diffuse pattern of tumor growth is usually seen in older children, as it makes the retina thick and causes delayed diagnosis.

Vertebral compression fracture (VCF) is characterized by the collapse of one or more vertebral bodies, which causes persistent and unbearable pain in patients. Osteoporosis, a degenerative bone disease, is the leading cause of VCF among the aging population. Other causes include metastatic bone disease, multiple myeloma, metastatic spinal tumors, and traumatic injuries. Individuals with VCF can undergo vertebroplasty and kyphoplasty to treat the condition. Both procedures are minimally invasive and conducted on an outpatient basis. They include the insertion of special bone needles through the tissues in the posterior wall on the back, and the injection of orthopedic cement into the vertebral body. The usage of two balloon devices makes.

The global human insulin market is expected to grow rapidly during the forecast period. Factors such as an increase in population with type 1 and 2 diabetes and the rise in disease awareness contribute to this growth. In addition, a rise in obese as well as the aging population is expected to further propel market growth. However, factors such as stringent regulatory environment, low diagnosis rate of diabetes, market competition from local players, inconvenient ROA, and poor storage conditions will hamper the market.

Minimal invasive surgery is a procedure performed through tiny incisions and advanced equipment, which is intended to reduce the damage to human tissue during surgeries. It is a complex surgical procedure used for the treatment of conditions such as CVDs and bone, gastrointestinal, and spinal disorders, among others. This type of surgery has equivalent outcomes as a traditional open surgery. The benefits of minimal invasive surgeries include quick recovery, shorter hospital stays, and less pain and scarring to patients.

目的探究术后使用自制生肌膏肛旁脓肿创面痊愈情况。方法将符合纳入标准的80例单纯性低位肛旁脓肿术后住院患者,采取随机数字表法随机分为对照组和治疗组,每组各40例。治疗组在肛周涂抹自制生肌膏并行纱布覆盖,对照组在肛周涂抹马应龙麝香痔疮膏并行纱布覆盖。采用VAS疼痛评分方法评估2组的疼痛情况并用肉芽组织评分标准评估肉芽生长状况。结果与第1天比较,2组用药后3、7、15 d VAS评分均降低(P<0.05);2组第1天VAS评分比较差异无统计学意义,治疗组第3、7、15天疼痛程度VAS评分均小于对照组(P<0.05)。治疗组平均疼痛持续时间短于对照组(P<0.05)。与第1天比较,2组用药后3、7、15 d肉芽组织评分均降低(P<0.05);2组第1天肉芽组织评分比较差异无统计学意义,治疗组第3、7、15天肉芽组织评分均小于对照组(P<0.05)。结论自制生肌膏对创面疼痛有明显缓解作用,对肉芽组织生长有明显促进作用,对于肛痈后促进创面愈合疗效优于马应龙麝香痔疮膏。

目的：观察反式白藜芦醇对阿尔茨海默病(Alzheimer's disease，AD)模型小鼠记忆损伤的改善作用。方法：小鼠随机分为假手术组、模型组和反式白藜芦醇10，20，40mg·kg-1组。在小鼠海马CA1区注射Aβ25-35后给予反式白藜芦醇10d，采用水迷宫试验观察药物对小鼠学习记忆的影响，免疫组化法观察各组小鼠海马CA1区神经元可塑性变化，western-blot法检测神经可塑性相关蛋白的表达变化。结果：40mg·kg-1反式白藜芦醇能明显缩短AD小鼠寻找平台的潜伏期，增加原平台所在象限的停留时间和穿越次数；20，40mg·kg-1反式白藜芦醇能增加海马CA1区神经元顶端树突的长度和树突的密度；40mg·kg-1反式白藜芦醇能增加AD小鼠海马CA1区BDNF、pCREB以及c-fos蛋白的表达。结论：反式白藜芦醇能逆转Aβ引起的小鼠的学习记忆损伤，其机制可能与改善海马神经元的神经可塑性有关。

目的：研究碳青霉烯类抗菌药物敏感性下降肠杆菌科细菌的耐药情况及产碳青霉烯酶基因型。方法：对临床分离到非重复的36株耐碳青霉烯类肠杆菌科细菌，应用改良Hodge试验进行产碳青霉烯酶的表型确证，PCR扩增技术分析产碳青霉烯酶基因型。结果：药敏试验显示36株碳青霉烯类耐药肠杆菌科细菌具有对第3，4代头孢菌素、碳青霉烯类、氟喹诺酮类和酶抑制剂复合制剂等多重耐药。36株菌株中有16株改良Hodge试验阳性；PCR结果10株细菌携带blaKPC，未检出blaIMP、blaVIM、blaGIM、blaSIM、blaNDM-1基因条带。结论：产KPC酶是台州医院碳青霉烯类抗菌药物敏感性下降肠杆菌科细菌的主要耐药机制，其中KPC是主要基因型。

Most cancer-related deaths arise from metastasis produced by circulating tumor cells (CTCs). A new concept of this research is that circulating cancer stem cell (CSC)-platelet aggregates (CSCPA) represent the most aggressive subset of CTCs responsible for breast cancer metastasis. The goal of this proposal is to identify and count CSCPAs in vivo in preclinical models of metastatic breast cancer, and to define the correlation of CSCPA amount with metastasis development. We developed a novel, in vivo multicolor photoacoustic (PA) flow cytometry (PAFC) platform for the detection of CSCPAs using the principle of flow cytometry, negative and positive PA contrasts, multispectral high-pulse-repetition-rate lasers, bioconjugated nanoparticles and a mouse model of human breast cancer. Using this approach, we provided a proof-of-concept for highly sensitive detection of CSCPAs and individual CSCs in real biological environments in a whole body in vivo. For the first time, we demonstrated the ability of CSCs to form aggregates with platelets (CSCPAs) in blood circulation of tumorbearing mice. Furthermore we showed that the number of CSCPAs increased during development of metastatic disease. Obtained preclinical results can advance general understanding of cancer stem cell biology and metastasis progression as well as will be used as the basis for initiating highly innovative clinical research in cancer patients.

Our main goal in this proposal was to investigate the capacity for quantitative in vivo MRI biomarkers to represent underlying molecular signatures of DCIS, using the preclinical genetically engineered mouse (GEM) model framework to our hypotheses. We focused three key molecular pathways Rb, p53, BRAC1 and whether MRI signatures can identify these molecular subtypes of disease. This report describes our experience in the first six months executing the SOW. We soon discovered limitations in our original GEM modeling strategy suggesting that our proposed studies could not be effectively performed. We therefore designed an alternative GEM modeling strategy that successfully addressed these limitations. We also developed novel MRI techniques to detect, characterize and follow progression of the preinvasive malignancies in the mouse mammary gland at high spatial resolution, and high frequency (rapidly imaging every few days).