所谓痛点，既包含了中国医药产业当下的软肋与弱点，也有大众健康需求的空白点、企业战略发展中的盲点，更有对未来升级支点的迷茫或是不确定。只有对痛点领悟，才能找准突破点——陶剑虹喻之为“新常态下让产业飞的风口"。 “未来，传统实业向产业互联网时代迈进，是不可阻挡的潮流。数据重构商业，流量改写未来，旧模式渐渐消失，与之替代的，将是融合式创新的变革。"11月6日下午，在第26届全国医药经济信息发布会上，CFDA南方医药经济研究所副所长、医药经济报总编陶剑虹博士，用别开生面的互联网语言，为现场近千名医药人士勾勒出中国医药转型升级的大格局。

本文介绍了美国、英国、澳大利亚3个畜牧业大国动物疫情应急管理的实践，总结了在动物疫情应急管理中一些经验及教训。基于中国目前动物疫情应急管理的形势，提出了国外动物疫情应急管理对中国的一些启示，为中国完善动物疫情应急管理，促进畜牧业健康发展。

报告从政策环境、市场行情、厂商动态、科技研发、国际资讯、行业数据、分析评论等几个方面对医药行业进行了分析评论。

报告从医药行业事件分析、竞争环境、竞争对手、行业数据等几个方面进行了分析评论。

Overactive bladder (or overactive bladder syndrome) is a urological condition characterized by storage symptoms such as urgency, changes in the frequency of urination, nocturia, or incontinence. Although not a life-threatening condition, it is often debilitating and stigmatized. The pathophysiology of overactive bladder is not characterized completely. The symptoms can be lifelong or relapsing and remitting or it can be resolved. An overactive bladder can affect anyone irrespective of their gender. It is caused by the abnormal contraction of the detrusor muscles of the bladder. An overactive bladder can also be related to neurological diseases such as Parkinson's disease and multiple sclerosis.

Epilepsy is a spectrum of brain disorders varying from benign to severe, disabling, and lifethreatening symptoms. It is caused by various factors ranging from brain malformations and tumors to meningitis, high-risk pregnancies, and birth trauma. However, when the underlying cause of the disease is unidentified, as in the majority of the cases, it is known as idiopathic epilepsy. Epilepsy is characterized by repeated occurrence of generalized or focal seizures. An imbalance between the inhibitory and excitatory signals of the brain, leading to a sudden onset of excitation, results in seizures. Occurrence of two or more unprovoked seizures is an important criterion to diagnose a person as being epileptic.

相对完善的药品生产和流通体制是保障英国医疗卫生体系能够向居民全面提供普遍、优质和可持续医疗卫生服务的关键环节。本文主要从以下方面介绍英国药品生产和流通体制的经验：（1）国民医疗卫生服务体系是英国医疗卫生能力的核心，具有分级保健、医疗服务购买与提供分离、分区域单独管理和医药分开等特点。（2）英国实行生产许可和上市许可分离的管理制度；有效的管理促进形成了具有较强国际竞争力的制药产业，表现为产业集中度高、全球市场份额较高，研发创新能力强和对经济增长贡献大等方面：（3）英国具有比较完善的药品流通体系，鼓励自由竞争，配送费率整体较低，批发商从传统物流向综合服务提供商转变。药品价格管理载体是NHS 偿付价格，并按品牌药和非专利药的划分采取不同价格管理方式。在药品采购机制上，对品牌药和非专利药采取不同的采购方式。（4）英国着重从建立生命科学生态系统、鼓励研发和成果产业化、提高监管效率等方面支持医药产业发展。基于英国经验，结合我国医疗卫生体制改革的实践，获得以下启示：一是医疗卫生体制尚未出现完美模式，世界各国均在探索之中；二是公立医院改革需要建立完善的法人治理结构；三是实行药品生产许可和上市许可分离管理可以提高监管效率；四是药价管理要建立在药物经济学评价基础上，并尽可能发挥市场机制的作用；五是发挥好大型连锁式零售药店在药品流通中的重要渠道作用；六是应从产业链的视角采取多种政策手段支持医药产业发展；七是要重视发挥独立机构在维护公众健康利益方面的重要作用。

解热镇痛药物是国际医药市场上销量极大的大宗药物，其年销售数量合计高达二十多万吨。据西方著名咨询公司MINTEL报道，2013年全球解热镇痛类药物总销售额约有386亿美元左右，年复合增长率在4%。随着世界多个国家进入老龄化社会，而老年人病痛多，敌对解热镇痛药类产品亦在逐年增长。除了口服型镇痛药制剂外，过去几年里国际市场上治疗骨关节炎引起的走路疼痛、运动引起的肌肉酸痛以及神经性疼痛症的外用型制剂销量猛增，并成为推动全球解热镇痛药物市场快速增长的新动力。虽然已上市的解热镇痛药物品种多达数十个，但国际医药市场上至今仍由几只老品种继续主宰市场，例如扑热息痛、阿司匹林、布洛芬和双氯芬酸等4只经典老药销量合计约占全球解热镇痛药市场总量的近7成，表明老药仍为市场的中坚产品，包括COX-2在内的镇痛新药难以撼动老产品的市场垄断地位。如据MINTEL公司的报告中披露：2013年发达国家市场上最畅销的7只解热镇痛药物(按其销售数量排名)依次为：1.扑热息痛2.阿司匹林3.双氯芬酸4.安乃近5.布洛芬6.酮替芬和7.萘普生。据该报告中的结论，上述7只产品销售额合计约占西方国家解热镇痛药物市场总份额的7-8成，而其它几十只镇痛药物销售额合计仅占剩余2-3成份额。表明老药仍主宰着西方解热镇痛药市场。

Decreased heart rate variability (HRV) is a marker of autonomic dysfunction and has been associated with future cardiac morbidity and mortality. HRV has been inconsistently associated with exposure to particulate matter (PM) air pollution. Fewer studies have examined whether air pollution exposure is a risk factor for cardiac arrhythmias. We aimed in this study to evaluate the relationships of heart rate variability and cardiac arrhythmias to PM exposures. Heart rate variability and arrhythmias were measured with ambulatory electrocardiographs using available raw data collected in a cohort panel study the National Institutes of Health, National Institute of Environmental Health Sciences (funded by NIH NIEHS R01 ES-012243). Electrocardiograph data (8,952 person-hours) were collected in 50 nonsmokers with coronary artery disease age 71 years and older living in four retirement communities in the Los Angeles air basin. Exposures included hourly markers of traffic-related PM and secondary organic aerosols, daily size-fractionated particle mass, and hourly outdoor criteria gases. Subjects were genotyped for the glutathione S-transferase M1 and T1 null (risk) alleles. Repeated measures regression analyses were adjusted for actigraph-derived physical activity and heart rate, temperature, day of week, season, and community location.

Tobacco use is the leading cause of preventable death in the United States, causing more than 440,000 deaths annually and resulting in $193 billion in health-related economic losses each year, $96 billion in direct medical costs and $97 billion in lost productivity. Since the first U.S. Surgeon Generals report on smoking in 1964, more than 29 Surgeon Generals reports, drawing on data from thousands of studies, have documented the overwhelming and conclusive biologic, epidemiologic, behavioral, and pharmacologic evidence that tobacco use is deadly. This evidence base links tobacco use to the development of multiple types of cancer and other life-threatening conditions, including cardiovascular and respiratory diseases.